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Re:GLP-1 drugs led to weight loss and reversed depression-li... by dmayle on Saturday June 27, 2026 @10:37PM (#48703826)
The issue isn't food addiction, it's a broken hunger response (broken by Howard Moskowitz intentionally in the name of profits)...

You have to change your food regimen completely (higher fiber, more protein, less sugar, less carbs, less fat), and that's tough to do when you're surrounded by options that aren't...

I think the real problem is that the symptom we're trying to treat is "overweight", and it's actually a two-stage problem... Fix the hunger response... and only then work on fixing the weight... Fixinig the latter without fixing the former means you'll always gain the weight back, fixing the former doesn't guarantee you lose weight (and is only temporary, if you're using drugs for it)... You have to go after both problems.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by basch on Saturday June 27, 2026 @11:01PM (#48703939)
We shouldn’t ignore grocery stores and marketing.

Aisles and aisles of sugar drinks and colorful sugar packaging.

The way society leaves it up to people to make their own decisions creates the problem at scale.

Society essentially has to take weekly injections to avoid the temptation of coca cola.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by mynameisash on Saturday June 27, 2026 @11:23PM (#48704020)
What breaks the hunger response, and how does one fix it?

Maybe it's well-known, but I read the starvation response Wikipedia page[0] and didn't grok it.

[0] https://en.wikipedia.org/wiki/Starvation_response

Re:GLP-1 drugs led to weight loss and reversed depression-li... by SoftTalker on Saturday June 27, 2026 @11:37PM (#48704095)
Buy unprocessed food and prepare it yourself. Don't add sugar. Eating processed food and even most restaurant food is eating food that's designed to make you want more, not satiate you.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by mynameisash on Saturday June 27, 2026 @11:57PM (#48704194)
I guess I should have asked about the technical mechanism of what causes and what actually 'breaks', and then what the technical remedy is.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by habinero on Sunday June 28, 2026 @03:18AM (#48705161)
Yeah, that does nothing. I love to cook, and I can cook super healthy and like it. I'm still hungry lol.

There's a part of my brain that constantly thinks about food. It's like tinnitus. GLPs stopped that cold.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by SoftTalker on Sunday June 28, 2026 @11:06AM (#48707969)
Do you have addictive/compulsive tendencies in other things besides eating? Did GLPs reduce those as well (I've heard that it does)?

For me, stopping fast food, most restaurant/takeout food, and processed food such as bread, pastries, chips, cookies, and any prepared/convenient "snack" items drastically reduced how often I felt hungry or just wanted to eat for no apparent reason.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by habinero on Monday June 29, 2026 @04:02PM (#48724377)
No, I don't have anything like that. I have a friend with diagnosed OCD and that is an entirely different beast. And I have tried cutting that stuff out (was never big on most of it anyway) and it did absolutely nothing for this sort of thing lol.

Tinnitus really is the best way I can describe it. I didn't even realize how pervasive it was until it shut off.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by dmayle on Sunday June 28, 2026 @10:19PM (#48714052)
For me, the simple shift of moving to eating 0.7g of protein per pound of body weight every day did it... It was not enough on it's own (I also eat more fiber, less fat, less carbs, though less does not mean none), but that alone was a night and day difference, and enough to change the story.