GLP-1 drugs led to weight loss and reversed depression-like behavior in mice

Re:GLP-1 drugs led to weight loss and reversed depression-li... by LaurensBER on Saturday June 27, 2026 @07:00PM (#48702601)

I've gained and lost 10kg twice in my life. Maintaining the weight loss isn't that hard once you've a rhythm dialed in.

In my case I just weight myself daily, track the weight and scale my food consumption with the current trend. If I'm gaining weight I'll skip a meal.

It takes a while to figure out what works for you but I can tell you that making small lifestyle changes to maintain your weight is fairly easy compared to figuring out how to lose 10 kg.

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Re:GLP-1 drugs led to weight loss and reversed depression-li... by coffeemug on Saturday June 27, 2026 @07:38PM (#48702884)

When I was lifting weights I went from 170lbs to 210, and back to 170. Doing that isn’t technically hard, and maintaining is even easier. But I had to think about it _all_ the time. Maybe it’s because I’m older now, but I just don’t want to spend that much effort thinking about food.

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Re:GLP-1 drugs led to weight loss and reversed depression-li... by faangguyindia on Saturday June 27, 2026 @10:15PM (#48703709)

lifting weight isn't efficient for weight loss.

Without calorie deficit, you'll not lose much weight by lifting alone.

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Re:GLP-1 drugs led to weight loss and reversed depression-li... by SoftTalker on Saturday June 27, 2026 @11:41PM (#48704115)

You'll probably gain weight in fact. Muscle is heavier than fat.

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Re:GLP-1 drugs led to weight loss and reversed depression-li... by kolinko on Saturday June 27, 2026 @07:07PM (#48702666)

Just because it wasn’t hard for you doesn’t mean it isn’t hard for the others. Grom what you said it seems you just had some bad habits you had to fix and that’s it.

[ Parent | on HN ]