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A comment on CRISPR Tech Selectively Shreds Cancer Cells, Including "Undruggable" Cancers. Parent comment

Re:CRISPR Tech Selectively Shreds Cancer Cells, Including "U... by im3w1l on Friday June 12, 2026 @02:19PM (#48507565)
Naively, I would deal with this by deciding how many cells I want to kill each day and then figure out a dosing schedule that achieves that. Or maybe it's better to do one dose every few days. But yeah either way.
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Re:CRISPR Tech Selectively Shreds Cancer Cells, Including "U... by spligak on Friday June 12, 2026 @07:02PM (#48510403)
> I would deal with this by deciding how many cells I want to kill each day

Yes, this is an approach. This starts to exceed my understanding of the problems the teams are facing - but there are concerns about the efficacy of Cas12a2-based approaches fading. Not because the cells adapt, but because your immune system starts acting funny in the presence of the payload.

I don't recall the specifics but there seems to be a window of opportunity for these things.

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