Vibe coding my way to a healthy family: Introducing Gamow Labs

Re:Vibe coding my way to a healthy family: Introducing Gamow... by arjie on Wednesday June 10, 2026 @04:03AM (#48473029)

Huh, this is fascinating. My wife and I did IVF with WGS in order to find a much less catastrophic shared genetic condition[0]. We have the FASTQs for my parents, and brother, and my wife and me, and our daughter (and our other embryos) and I've run it through the standard Opus[1] (since 4.5) and none have contradicted our genetic counselors or IVF doctors. This is an interesting, and devastating, condition far more severe than anything we risked. More power to the author for having coped in a productive way. I hope that more such science will lead to healthier babies, parents more comfortable with children since they know what they can avoid or mitigate, and happier families.

As an aside, I have not found SF to be anti-natal but that's because of the community we've formed. Of our friends in SF, almost all are trying for children or have them. Our shared Slack group is full of happy news. Inevitably, many of us must move elsewhere in order to allow them some freedom[2] and good education[3]. So there's a bit of a dead-sea effect, true, but even within that sea there are pockets of community one can find.

0: https://wiki.roshangeorge.dev/w/IVF but also see https://viz.roshangeorge.dev/roshan-genvue/ to see an old set of results and download my VCF here https://my.pgp-hms.org/profile/hu81A8CC and put it through a modern (but not too modern LLM) to get some fun results if you want a starter data set to peek through. Opus can get you far.

1: Fable as expected yields:

     Fable 5's safety measures flagged this message for cybersecurity or biology topics. They may flag safe, normal
    content as well. These measures let us bring you Mythos-level capability in other areas sooner, and we're working
    to refine them. Switched to Opus 4.8. Send feedback with /feedback or learn more

2: Within the last year 2 children have been killed in our neighbourhood by drivers, and parents in the US already compensate by cutting child freedom significantly

3: Since school system design is determined by both parents and non-parents, it is a vehicle of expression of non-education-related action by the latter, and in a city where they dominate the former, the effects are typical

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Re:Vibe coding my way to a healthy family: Introducing Gamow... by fyrn_ on Wednesday June 10, 2026 @04:52AM (#48473423)

The valley is extremely anti natal, it shows up in large scale demographic data very clearly, just check the census

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Re:Vibe coding my way to a healthy family: Introducing Gamow... by dmckinno on Wednesday June 10, 2026 @08:58AM (#48475625)

Opus-4.8/GPT-5.5 coupled with their respective harnesses will do a good job for more vanilla cases, I realized a custom harness and set of skills and MCP servers became essential as complexity increased (mostly hard SVs). I'll get an eval and more technical post out in a few weeks.

If you are open to chatting about your experience, I'd love to hear from you. I spend a lot of time learning from and supporting other rare disease families these days.

And the anti-natal thing was kind-of joking not joking. I do know lots of people with kids there now, but when my wife first got pregnant, we were alone.

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Re:Vibe coding my way to a healthy family: Introducing Gamow... by arjie on Wednesday June 10, 2026 @11:30AM (#48477856)

Certainly. If there’s something I can do for you that will assist I’m happy to do so. Email on profile and I don’t mind chatting in person in SF should you so desire.

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