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A comment on Scientists believe ibogaine can help veterans overcome PTSD. Parent comment

Re:Scientists believe ibogaine can help veterans overcome PTSD by Trasmatta on Sunday May 17, 2026 @10:56AM (#48169487)
DXM is also the active ingredient in the antidepressant Auvelity (combined with bupropion)

Lot of interesting studies and anecdotes on its efficacy as an antidepressant

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Re:Scientists believe ibogaine can help veterans overcome PTSD by firebot on Monday May 18, 2026 @05:17AM (#48177137)
A small dose of DXM boosts the effectiveness of Wellbutrin by 10x or so. It's not an antidepressant itself. It's a dissociative and cough suppressant.
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Re:Scientists believe ibogaine can help veterans overcome PTSD by Trasmatta on Tuesday May 19, 2026 @07:28PM (#48201050)
This is incorrect. DXM is the active ingredient in Auvelity. Bupropion is included because it inhibits the enzyme that breaks down DXM quickly. The bupropion boosts the effectiveness of DXM as the primary antidepressant, NOT the other way around like you're suggesting.
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