Human brain changes after first psilocybin use

Re:Human brain changes after first psilocybin use by g-technology on Thursday May 07, 2026 @12:22AM (#48045355)

I think the issue there is that the ssri dull some of the receptors that psilocybin act upon.

If you are on them, you can still get positive results, but your baseline for microdose might be higher. Be careful if try… go slow, follow proper harm reduction measures.

[ Parent | on HN ]

Re:Human brain changes after first psilocybin use by grvdrm on Tuesday May 12, 2026 @04:30PM (#48114098)

Not a doctor but I might go further and say possibly avoid altogether until you come off SSRI.

I have a recent experience with MDMA, a substance that also interacts with those receptors. A friend and I both tried MDMA, not first realizing that one of us felt almost no effect because of an ongoing Lexapro prescription. We were well supervised in this endeavor, but I can imagine a more unrestricted experience in which you take way more than a recreational dose by accident.

By the way, you might need those SSRIs!

[ Parent | on HN ]