It is nice to know when confronted with new information that they might revise their stance too.
I mean, curing all disease isn't something where progress is linear. A large portion of the work is done upfront before you see any result. Then when your knowledge base and methodology is sufficiently robust, many disease can then be cured in quick succession. The fact that they have no visible success after 10 years says little about the viability of their goal.
Looking at the history of modern medicine, the cure rate of diseases was not exponential, it was gradual over the course of hundreds of years.
Sure there were a few big jumps- water sanitation and antibiotics come to mind- but if you look at cured cardiovascular diseases, cancers, GI diseases etc., they all started with bad treatments that indeed slowly improved over decades.
If CZI is looking to eliminate all disease in a lifetime (say 100 years) I would expect some progress.
Chan Zuckerberg is NOTORIOUS for overly ambitious claims, the Chan Zuckerberg Initiative started in 2015 with the bold statement they would "cure all disease in our lifetime." It's been 11 years. Have they cured 1 disease? Let alone ~all~ disease? No.
When Zuckerberg realized he probably wasn't going to hit this goal they quietly changed it to "within our children's lifetimes."
I used to work in their building and actually saw them change it on the wall and as "within our childrens" 3 years in. Stay posted, probably in 15 years they buy themselves some more time and make it "our children's children's lifetimes."