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Re:Why Early Detection Is the Best Way to Beat Cancer by bryanlarsen on Friday November 16, 2012 @11:08AM (#4794373)
There are huge drawbacks to early detection, though. Surgery, radiation therapy and chemo-therapy are very invasive techniques, doing huge amounts of damage to a person's body as well as to the cancerous cells. It very often is the case that the cure is worse than the disease. Early detection also submits people to the huge mental stress of thinking that they're going to die soon.

And that's the case even if the early detection techniques were perfect. They aren't, far from it. They have a significant false positive rate. Many people who don't have cancer are subjected to the mental and physical stresses of cancer treatment. They then think that this treatment saved their lives, so they say to everybody they know: go get tested!

The other problem is the prevalence of cancer. 80% of men in their 70s have prostate cancer. Some of them will die from it, but most will die from heart disease or another cause. Treating them for prostate cancer will cause a huge decrease in their quality of life for no benefit.

Yes, early detection of cancer is a very potent tool for saving people's lives. But it's not a panacea.

[EDIT: the article actually does discuss most of these issues, I just wanted to try and balance things. Read the article.]

Re:Why Early Detection Is the Best Way to Beat Cancer by elemeno on Friday November 16, 2012 @11:35AM (#4794501)
Except that early stage intervention tends to mean that less invasive techniques can be used. Removing a small cancerous lump might only require keyhole surgery, while in later stages it might require significantly more invasive surgery. Sure, all surgery carries some risk (much of which, I believe, comes from having to use anesthetics rather than the surgery per-se) but the less invasive it is, the faster the patient can recover from it. Similarly, early stage cancers might call for far less agressive chemotherapy drugs with reduced side-effects and requiring fewer doses.

Still, the question of early detection is an interesting one, as is the question of when intervention is necessary. Your comments about the stress of knowing that you might have cancer is interesting in light of a paper which my father published a few years ago about whether to restart treatment with people who had relapsed ovarian cancer when their tumour marker levels started rising again, or when they started to exhibit symptoms. As it turned out, while treating people once their tumour markers crossed a 'red line' meant that intervention started earlier, waiting for symptoms to be exhibited resulted in nearly identical life expectancy and also a higher quality of life as they'd spent less time on chemo. Consequently, it also raised the question of whether or not it's worth regularly checking tumour marker levels after their first cancer had gone into remission, as having to have blood tests every three months and waiting for results each time is stressful in itself.

Re:Why Early Detection Is the Best Way to Beat Cancer by brazzy on Friday November 16, 2012 @11:36AM (#4794504)
> Surgery, radiation therapy and chemo-therapy are very invasive techniques

A not so well-known fact to drive that home: cytostatics (the bulk of traditional chemotherapy) are derivatives of some of the nastiest chemical weapons developed in WWI, specifically mustard gas.

Re:Why Early Detection Is the Best Way to Beat Cancer by elemeno on Friday November 16, 2012 @11:49AM (#4794580)
More than that, Mustard Gas was fairly important in the development of chemotherapy after US Army Doctors noticed it's effect on white blood cells following an air raid in WW2 when a ship carrying Mustard Gas was bombed. From there, in part, was sparked the idea of using similar drugs to attack cancers.

http://www.the-hospitalist.org/details/article/243771/From_W... http://en.wikipedia.org/wiki/Sulfur_mustard#Development_of_t...

Re:Why Early Detection Is the Best Way to Beat Cancer by corbet on Friday November 16, 2012 @12:01PM (#4794639)
Indeed, it's worth reading some of the stuff people like Otis Webb Brawley have written on the subject. Early screening for prostate cancer has indeed reduced the deaths attributed to that disease — because the resulting treatments are killing patients before the cancer could. It's not always as simple as it seems.
Re:Why Early Detection Is the Best Way to Beat Cancer by mikerg87 on Friday November 16, 2012 @02:03PM (#4795320)
I have lived with canner in two loved ones very close to me. My wife and my Dad. My wifes TNBC was caught early and and the treatment was horrific but she has survived. I wasn't so lucky with my Dad as he came out of the gate with prostate cancer, stage IV, earlier detection in his case would have given me the time for fishing and the other things we'd put off for his retirement.