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A comment on Ah, peptides. where to begin?. Parent comment

Re:Ah, peptides. where to begin? by stouset on Tuesday April 07, 2026 @02:38AM (#47671491)
If only there were a federal administration whose responsibility it was to collect data about food and drugs so we could rely on something more than anecdotes from random strangers on the Internet.
[ Parent | on HN ]
Re:Ah, peptides. where to begin? by JumpCrisscross on Tuesday April 07, 2026 @02:49AM (#47671557)
Do you have a link to those data showing GLP-1 agonists are ineffective?
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Re:Ah, peptides. where to begin? by rzmmm on Tuesday April 07, 2026 @03:29AM (#47671831)
I emphasize it's like the drug disulfiram: Very effective as long as patients take the full dose, but the lack of real-world efficacy stems from the difficulty in adhering to the treatment.

This study found that 84.4% non-diabetic patients stop taking GLP-1 drugs within two years. https://jamanetwork.com/journals/jamanetworkopen/fullarticle...

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Re:Ah, peptides. where to begin? by JumpCrisscross on Tuesday April 07, 2026 @05:40AM (#47672715)
> the lack of real-world efficacy stems from the difficulty in adhering to the treatment

Do you have a source for this "lack of real-world efficacy"?

> This study found that 84.4% non-diabetic patients stop taking GLP-1 drugs within two years

"With a with a median on-treatment weight change of −2.9%" [1]. Of those who discontinued and experienced "weight gain since discontinuation," they were "associated with an increased likelihood of GLP-1 RA reinitiation."

I'm genuinely struggling to see how this source shows real world inefficacy. In my friends, all of them stopped taking GLP-1 drugs within 2 years because all of them lost the weight they wanted to.

Out of curiosity, what sources lead you to believe this?

> it's like the drug disulfiram

Have clinicians made this connection?

[1] https://jamanetwork.com/journals/jamanetworkopen/fullarticle...

[ Parent | on HN ]
Re:Ah, peptides. where to begin? by stouset on Tuesday April 07, 2026 @10:48AM (#47676289)
You didn’t come here with data. You came here with anecdotes and asserted that they were conclusive.
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