Eh, the main downside in the short run is that you are killing your gut fauna.
> One of the risks of an always on response, is if something evolves to evade it - you have nowhere to go.
Evolution can't look into the future. (And eg bats are pretty much always on with their immune system.)
Sure. But yesterdays mistakes can be punished today. ie all evolution happens in retrospect - a mutation haopens - the world tells you after the fact whether that was good or bad. Evolution is hindsight in action. In hindsight - taking antibiotics everyday might have been a bad idea.
> Eh, the main downside in the short run is that you are killing your gut fauna.
Sure - thus increasing your chances for being colonised by an unfriendly and antibiotic resistent bug - which may result in your death - which in hindsight was obviously a bad idea....
One of the risks of an always on response, is if something evolves to evade it - you have nowhere to go.
It's why taking an antibiotic at breakfast everyday is not a good idea.