It's not the odds of the breakthrough, but the timeline. A factory worker could have correctly seen that one day automation would replace him, and yet worked his entire career in that role.

There have been a ton of predictions about software engineers, radiologists, and some other roles getting replaced in months. Those predictions have clearly been not so great.

At this point the greater risk to my career seems to be the economy tanking, as that seems to be happening and ongoing. Unfortunately, switching careers can't save you from that.