In wxWidgets you use sizers, so you don't work on pixel-level alignments. I can understand if you're using an ancient framework like MFC, but even then I seem to recall there was a sizer equivalent system (or it is easy enough to write a class to do so, moving components).

I think it is a daft thing to move to shipping a colossal web framework and entire browser simply because of 1px UI alignments (which have been a solved problem for decades in C++ anyway).