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A comment on Drug trio found to block tumour resistance in pancreatic cancer. Parent comment

Re:Drug trio found to block tumour resistance in pancreatic ... by apparent on Thursday January 29, 2026 @01:18PM (#46814132)
This isn't quite as bad as the garden variety "in mice" studies:

> The combination therapy also led to significant regression in genetically engineered mouse tumours and in human cancer tissues grown in lab mice, known as patient-derived tumour xenografts (PDX).

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Re:Drug trio found to block tumour resistance in pancreatic ... by ramesh31 on Thursday January 29, 2026 @01:27PM (#46814268)
>"The combination therapy also led to significant regression in genetically engineered mouse tumours and in human cancer tissues grown in lab mice"

Required XKCD: https://xkcd.com/1217/

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Re:Drug trio found to block tumour resistance in pancreatic ... by apparent on Thursday January 29, 2026 @01:30PM (#46814315)
Is PDX considered to be illegitimate? Would be curious to know if prior studies that showed success with PDX methods ultimately resulted in useful therapeutics.
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Re:Drug trio found to block tumour resistance in pancreatic ... by tiahura on Thursday January 29, 2026 @01:37PM (#46814441)
Vorinostat
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Re:Drug trio found to block tumour resistance in pancreatic ... by stultissimus on Thursday January 29, 2026 @05:01PM (#46817333)
PDX is a double edged sword. Human tumors are engrafted into mice with no immune system. Immune-cancer interface is incredibly important, yet completely lacking in these models. Consider that some of the greatest cancer drugs ever work specifically on the immune system (e.g. checkpoint inhibitors like Keytruda).
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Re:Drug trio found to block tumour resistance in pancreatic ... by DennisP on Thursday January 29, 2026 @08:02PM (#46819298)
A drug that works even without help from the immune system seems like it might be even better. It's hard to imagine how the immune system might interfere, since it doesn't interfere with other drugs.
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