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Re:Vitamin D and Omega-3 have a larger effect on depression ... by corv on Thursday January 29, 2026 @10:02AM (#46811109)
I’ve heard this before that common doses are unnecessarily high but why is that? Patents?
Re:Vitamin D and Omega-3 have a larger effect on depression ... by zemvpferreira on Thursday January 29, 2026 @10:19AM (#46811354)
Rather, lack of. Melatonin is over-the-counter, generic, badly understood by the people taking it and dosed according to personal preference which means marketing it is all abouy big numbers. Bigger number on package = more sales.
Re:Vitamin D and Omega-3 have a larger effect on depression ... by kstrauser on Thursday January 29, 2026 @11:37AM (#46812534)
They’re considered dietary supplements and not medicine, so they’re not meaningfully regulated in the way meds are.
Re:Vitamin D and Omega-3 have a larger effect on depression ... by quietsegfault on Thursday January 29, 2026 @10:37AM (#46811591)
> why is that

Why buy 1mg pill when you can buy 100mg pill?

Re:Vitamin D and Omega-3 have a larger effect on depression ... by temp0826 on Thursday January 29, 2026 @11:58AM (#46812869)
Even funnier is that often 0.25mg or 0.5mg is closer to the correct dose, and those sizes tend to be hard to find.

There actually is a condition that calls for extremely high (100mg+ doses), but it is a very rare thing, no one should ever consider that much without instruction from a doctor. But you'll find it right next to the normal <=5mg doses without any explanation.

Re:Vitamin D and Omega-3 have a larger effect on depression ... by calfuris on Thursday January 29, 2026 @12:55PM (#46813741)
The Natrol liquid isn't usually too hard to track down. They advertise it as 1 mg or 2.5 mg, but it's the same stuff, the bottle just direct you to take 4 or 10 mL respectively.
Re:Vitamin D and Omega-3 have a larger effect on depression ... by Projectiboga on Thursday January 29, 2026 @01:37PM (#46814445)
So 1ml (20 drops) would yeild an average dose of .25mg in that form.
Re:Vitamin D and Omega-3 have a larger effect on depression ... by Projectiboga on Thursday January 29, 2026 @01:35PM (#46814415)
The help aiding sleep is only one function for melatonin. The reason for higher suggested doses is due to its anti-oxident function. From personal experience melatonin needs to be paired with vitamin e to really clear out over night. I take vitamin e as I get into bed right before I take a melatonin sublingual. Another benefit of melatonin is that it upregulates our insulin receptors.