Trying to make a dent in the universe while we metabolize and oxidize our telomeres away is a constraint.

But to be more in the spirit of your comment, if you've used these systems at all, you know how many constraints you bump into on an almost minute to minute basis. These are not magical systems and they have plenty of flaws.

Real creativity is connecting these weird, novel things together into something nobody's ever seen before. Working in new ways that are unproven and completely novel.