I would say yes! I would consider not sandboxing your internet browsers because the integration isn’t fully there yet, but everything else works. A lot of Flatpaks are maintained by their developers so you get releases faster with a layer of separation from an otherwise “slow” distro.

In my humble opinion, consider Fedora instead because of Ubuntu and Snaps. You’ll have the flexibility of Flatpaks, RPMs, Snaps if you really want, etc. Some suggested immutable distros (Silverblue), but you can adopt a containerized workflow incrementally with regular Fedora so that you don’t run into its sticky corners.