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Re:Jonathan Blow has spent the past decade designing 1,400 p... by biophysboy on Thursday December 18, 2025 @11:52AM (#46315196)
He gets political.. Just as an example, he claimed that it was obvious that COVID was a lab leak in 2021. This is not obvious at all if you read Michael Worobey's rigorous work instead of rely on Blow's arrogant intuitions.

I will still play Jonathan Blow's next game, but I think he is a bit of a hack outside of game design.

Re:Jonathan Blow has spent the past decade designing 1,400 p... by bitexploder on Thursday December 18, 2025 @12:36PM (#46315892)
Most of us are grossly unqualified to provide opinions on any domain save some hyper specialized domain we invest years of effort into. I always think about that when reading comments on the Internet :)
Re:Jonathan Blow has spent the past decade designing 1,400 p... by thrance on Thursday December 18, 2025 @03:19PM (#46318106)
If only the tech gurus of the internet stayed in their lanes, or if people knew better than to take their beliefs from clueless entrepreneurs who got lucky once, the world would be a much better place. Alas, tis not the one we live in.
Re:Jonathan Blow has spent the past decade designing 1,400 p... by bitexploder on Thursday December 18, 2025 @06:18PM (#46320181)
A lot of skills in say, running a business, really do transfer. It is possible to gain expertise on how to run a small business and translate that to other realms of running a business. But it is also important, perhaps critical, to recognize limitations. The less similar the situation and environment the less that will transfer. Some times enough transfers that the insights are useful. Some times it is actively harmful to apply previous approaches. Recognizing the differences and what transfers is much harder but also a skill. Becoming skilled enough to help up until your limitations is how you can continuously be successful in domains you have no right to be. The irony is even then you may still not really be able to offer helpful insight.
Re:Jonathan Blow has spent the past decade designing 1,400 p... by biophysboy on Thursday December 18, 2025 @12:56PM (#46316136)
absolutely agree on this. Expertise is essential because it means familiarity w/ the domain methodology, not because you have a certificate
Re:Jonathan Blow has spent the past decade designing 1,400 p... by dismalaf on Thursday December 18, 2025 @01:22PM (#46316479)
The lab leak theory was always credible. Here in Canada there was a big scandal with Chinese scientists who worked for one of our labs who secretly transferred specimens from Winnipeg to Wuhan in 2019 and the subsequent police investigation went public in 2020.

Here's a good article that's basically a summary of events (as well as teaser for a book): https://www.thestar.com/news/insight/from-our-lab-to-theirs-...

Re:Jonathan Blow has spent the past decade designing 1,400 p... by biophysboy on Thursday December 18, 2025 @02:52PM (#46317713)
(Apologies to the thread..)

Its not credible: two viral lineages emerged from the market ~1 week apart before the world knew what covid was; they differ by 2 nucleotides; mutation rates are 1e-6 per base per passage; doubling time is about half a week. A group of sick animals better explains the phylogenetics w/ these constraints. Everything points against lab leak: location, timing, and genetics.

Re:Jonathan Blow has spent the past decade designing 1,400 p... by dismalaf on Thursday December 18, 2025 @04:08PM (#46318761)
You should google the definition of credible since it seems you don't know it... (Hint, it doesn't mean 100% true)

It really boils down to: do you trust a brutal communist dictatorship that has been attacking the West asymmetrically and wants to invade its neighbours to be honest?

Multiple Western governments believe it was a lab leak and coincidentally I'm sure, relations with China have been quite bad since.

Re:Jonathan Blow has spent the past decade designing 1,400 p... by biophysboy on Thursday December 18, 2025 @04:32PM (#46319078)
My evidence is genetic material; your evidence is state intelligence
Re:Jonathan Blow has spent the past decade designing 1,400 p... by dismalaf on Thursday December 18, 2025 @04:37PM (#46319135)
Your evidence is a Chinese claim of genetic material. They've certainly never covered anything up before...
Re:Jonathan Blow has spent the past decade designing 1,400 p... by biophysboy on Friday December 19, 2025 @09:10AM (#46326024)
Any conclusion about a pathogen origin requires phylogenetic evidence. Everything else is secondary. You could write a trillion intelligence memos in the absence of genetic evidence and get no closer to the answer.

If you want to deny sequence data that predate worldwide recognition and controversy related to COVID-19, OK. But the origin question can never be answered with this denial.