Re:Trials avoid high risk patients and underestimate drug harms
by OutOfHere on Monday December 08, 2025 @04:25PM
(#46197855)
Move generally, whenever you read the percentage of patients that are noted as having a particular side effect from a medicine, the real percentage is much higher.
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Re:Trials avoid high risk patients and underestimate drug harms
by Aurornis on Monday December 08, 2025 @05:47PM
(#46198715)
> whenever you read the percentage of patients that are noted as having a particular side effect from a medicine, the real percentage is much higher.
The patients self-report their own side effects, then the numbers go into the paper.
Are you suggesting the study operators are tampering with numbers before publishing?
Re:Trials avoid high risk patients and underestimate drug harms
by OutOfHere on Monday December 08, 2025 @06:33PM
(#46199185)
> Are you suggesting the study operators are tampering with numbers before publishing?
No, but did you not read the posted article? Firstly, trials don't select participants unbiasedly. Secondly, many trials are not long enough for the side effects to manifest. Thirdly, I have enough real world experience.
Re:Trials avoid high risk patients and underestimate drug harms
by throwawaylaptop on Monday December 08, 2025 @07:02PM
(#46199488)
Real world experience doesn't count on HN health articles. If it wasn't documented by a researcher paid via funding from his industry leaders, or a government official trying to fast track his hiring in the public sector for $800k a year, it basically didn't happen.
Re:Trials avoid high risk patients and underestimate drug harms
by hirvi74 on Monday December 08, 2025 @07:32PM
(#46199773)
This is why I encourage the reporting of any and all side-effects of any treatment to the FDA. Information withheld cannot be collected.
https://www.fda.gov/safety/medwatch-fda-safety-information-a...
Re:Trials avoid high risk patients and underestimate drug harms
by SoftTalker on Monday December 08, 2025 @04:35PM
(#46197966)
And this just goes to reinforcing the beliefs of those who are skeptical of medical research. "Trust the science" is all well and good in theory except when the scientists are telling you a selective, cherry-picked story.
Re:Trials avoid high risk patients and underestimate drug harms
by venturecruelty on Monday December 08, 2025 @04:51PM
(#46198153)
Strange how that line of thinking always winds up in places like "vaccines are bad" or "ivermectin cures COVID".