This already happened to me because of mouse usage. I’ve longed for a keyboard like this so I cam rest my right arm/hand which has significant damage and pain.

I am using this mouse because of that, and it works for me:

https://www.contourdesign.com/collection/contour-slidermouse

Iirc this keyboard was custom made for a user that only has one hand. A layered design would be better but harder for the average user to adapt to.