So either fire a rocket in space to circularize the orbit or reach more than Earth’s escape velocity 25,020 mph (11.186 km/s, 40,270 km/h) ~ Mach 32.6, due to some drag in air to thin for any kind of air breathing engine to work.
X-30 was aiming far lower ~Mach 20. Nuclear could make it more realistic than any form of chemical combustion. It might be physically possible using Hydrogen but you’re talking generating extreme thrust at vastly more extreme conditions than the space shuttle’s retry.
The issue, I think, is more about balancing drag and air intake at appropriate atmospheric densities for different speeds. An SR-71 Blackbird could fly at 85,000 feet continuously, and a MiG-25 set what I believe is still the air-breathing record max altitude by pulling a "zoom climb" (accelerating in higher-density air that the engines could use effectively, then pulling the stick back and coasting up through rarefied air too thin for the engines) to 38km or 123,000 feet.
Most experimental hypersonic aircraft use rockets because that's what works.
There's no theoretical limitation on how fast an air breathing jet can move. You just have to redesign everything every few mach numbers, and deal with the atmospheric drag.