Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin...
by JumpCrisscross on Thursday October 02, 2025 @06:51PM
(#45456524)
> telomeres aren't mentioned
The paper specifically mentions the engineered cells have "extended telomeres".
I have heard variants on this assertion:
"Two of the most prominent purported underlying causes of aging are chronic inflammation and senescent cells."
One thing that surprises me is that telomeres aren't mentioned.
I also don't understand how this is happening (is apoptosis somehow triggered?):
"Now, the Academy researchers demonstrate that SRCs reduce senescent cells, measured using a blue dye called SA-β-Gal, in multiple organs, including the brain, heart, and lungs."
The main mechanism of action appears to be:
"The therapeutic efficacy of MPCs is largely attributed to their paracrine actions, with exosomes playing a pivotal role in mediating these effects."
The researchers do not appear to fully understand how this is happening:
"Among the diverse geroprotective functions of SRCs in the brain and ovary, the restorative effect of SRC-derived exosomes on aged cells and their surroundings emerges as a key mechanism. Rejuvenation of aged cells by exosomes likely involves multiple pathways and targets."