News for hackers. Stuff that matters.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by chasil on Thursday October 02, 2025 @05:46PM (#45455997)
I don't think that the assertions are nonsense, but I don't understand how this works.

I have heard variants on this assertion:

"Two of the most prominent purported underlying causes of aging are chronic inflammation and senescent cells."

One thing that surprises me is that telomeres aren't mentioned.

I also don't understand how this is happening (is apoptosis somehow triggered?):

"Now, the Academy researchers demonstrate that SRCs reduce senescent cells, measured using a blue dye called SA-β-Gal, in multiple organs, including the brain, heart, and lungs."

The main mechanism of action appears to be:

"The therapeutic efficacy of MPCs is largely attributed to their paracrine actions, with exosomes playing a pivotal role in mediating these effects."

The researchers do not appear to fully understand how this is happening:

"Among the diverse geroprotective functions of SRCs in the brain and ovary, the restorative effect of SRC-derived exosomes on aged cells and their surroundings emerges as a key mechanism. Rejuvenation of aged cells by exosomes likely involves multiple pathways and targets."

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by JumpCrisscross on Thursday October 02, 2025 @06:51PM (#45456524)
> telomeres aren't mentioned

The paper specifically mentions the engineered cells have "extended telomeres".