Yeah unfortunately mirrors is no go due to efficiency requirements, but luckily read performance is not that important if I manage to completely offload FS/S3 metadata and small files to flash storage (separate zpool for Garage metadata, separate special VDEV for metadata/small files).

I think I'm going to go with 8x RAIDz2 VDEVs 10x HDDs each, so that the 20 drives in the internal drive enclosure could be 2 separate VDEVs and not mix with the 60 in the external enclosure.