Microbial metabolite repairs liver injury by restoring hepatic lipid metabolism

Re:Microbial metabolite repairs liver injury by restoring he... by ck2 on Thursday August 28, 2025 @01:22PM (#45054702)

10-HSA is a fatty-acid metabolite produced by Lactobacillus bacteria

Lactobacillus Plantarum is a super common probiotic that produces 10-HSA and other important metabolites

its commercial name is also known as lp299v which has been studied for decades, tons of studies

for example: https://www.mdpi.com/2073-4344/10/2/154

lp299v is extreme safe and can be taken in mega-doses however it will not colonize in the GI so would have to be taken routinely

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Re:Microbial metabolite repairs liver injury by restoring he... by 0cf8612b2e1e on Thursday August 28, 2025 @04:16PM (#45056572)

Wouldn’t it be easier to just take a gram of the metabolite itself vs hoping for long term colonization?

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Re:Microbial metabolite repairs liver injury by restoring he... by DaveZale on Thursday August 28, 2025 @05:03PM (#45057008)

yes, this is what's done with tributyrin which is a triester of butyric acid. You want to ingest either a butyric acid salt or an ester of butyric acid, since the butyric acid itself is really stinky.

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