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Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by fc417fc802 on Wednesday August 06, 2025 @07:47PM (#44819168)
> In our ancestors and every other animal around us? Yes.

Right so my point is, with no smooth optimization path towards X in a given species the question "why doesn't species just X" has a readily available answer - because biased random walks are fickle and the pathway likely convoluted. Whereas when a smooth optimization path is available it becomes reasonable to ask "then why isn't species doing X already"? Assuming a long enough timescale then there must be some selection pressure preventing it.

I agree that the ice age is a reasonable hypothesis. If we were exposed to repeated boom-bust cycles of extended duration (ie multi-generational) then it's at least plausible that we gained some mechanism dedicated to preventing us from adapting in that direction.

Still it's an entirely reasonable question that needs to be asked when considering the potential for serious side effects. If the hypothesis is that this is actively prevented for historical reasons then we should want to see the precise molecular mechanism hunted down in order to validate that. Keep in mind that an alternative hypothesis would take the general form that ramping it up causes serious deleterious side effects in the long term.

It's quite like Chesterton's fence. There must be a reason so we would do well to understand approximately what that might be before tinkering.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by JumpCrisscross on Wednesday August 06, 2025 @11:19PM (#44820242)
> it's an entirely reasonable question that needs to be asked when considering the potential for serious side effects

I agree about it being asked. A lot of times it isn’t being asked, but assumed.

I thought it was snake oil when announced. I’m now beginning to question if it’s closer to a weird vitamin that we face a systemic deficit of.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by cthalupa on Thursday August 07, 2025 @05:10AM (#44822284)
> I’m now beginning to question if it’s closer to a weird vitamin that we face a systemic deficit of.

There's some studies suggesting that a big part of what influences someone to naturally be fat or skinny is tied to natural production of the GLP-1 hormone. Post-prandial readings of serum level GLP-1 show significant differences in lean people vs. obese people, with obese people have much less.

We don't have an understood mechanism yet to determine if it's causative - maybe it's yet another feedback loop we have with gaining weight - but it seems very plausible that the natural level of production is a determinant factor in just how susceptible you are to packing on the pounds in today's food-rich world.