Except for some niche Janko-layout keyboards like the WholeTone Revolution and Lumatone, isomorphic pianos haven't every really caught on. However, isomorphic layouts are very common on accordions! I have a chromatic button accordion at home and credit it with making music theory finally "click" for me. On my fiddle I can play in keys of G,D,A (and the relative minors) quite easily but struggle on weirder keys and can't handle chords at all. On the accordion it couldn't be easier!