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Re:Google DeepMind Releases AlphaGenome by cysteinechapel on Monday June 30, 2025 @07:21PM (#44428977)
There are existing frameworks for integrating functional and statistical fine mapping methods (e.g. polyfun + susie/finemap). They use annotation overlaps like epigenetic or conservation tracks but can be extended to variant effect predictions from models like this. They essentially modify the prior probability of a variant being causal from uniform to one that depends on the functional annotation.

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