Proton relies on Linux sys APIs not available on macOS, but the Porting Toolkit is available. I've been able to "play" Noita on my M2 Air (granted the perf sucks, but that's what I get for owning an Air). This discussion hasn't been centered around kernel APIs, but rather graphics APIs (D3D/Vulkan), if you're going for that "gotcha!".

Crossover is another option, though I have no need to pay for it as I own a Windows PC/consoles.

https://www.reddit.com/r/linux_gaming/comments/gt3fat/proton...