I'm a big fan of pyca/cryptography and I use it for any serious project, but if I just need hashing I tend to use the standard library hashlib - it saves a somewhat heavy dependency, and the API is less verbose.

Also, pyca/cryptography uses OpenSSL. OpenSSL is fine, but has the same "problem" as the previous python stdlib implementation. (Personally I think it's an acceptable risk. If anything, swapping in 15,000 lines of new code is the greater risk, even if it's "verified")