It is literally impossible to securely talk to a different party over an insecure channel unless you have a shared key beforehand or use a trusted third-party. And since the physical medium is always inherently insecure, you will always need to trust a third party like a CA to have secure communications over the internet. This is not a limitation of some protocol, it's a fundamental law of nature/mathematics (though maybe we could imagine some secure physical transport based on entanglement effects in some future world?).

So no, IPSec couldn't have fixed the MITM issue without requiring a CA or some equivalent.