It always depends on what kind of project you're going to work on. My projects usually falls on the CRUD side.

For that, I keep using Django + Unpoly (check it out) + Bootstrap and I always get a SPA like app that works very fine.

And I keep my stack very lean. I'm also a backend developer so frontend stuff is just an annoyance. New language, new build pipelines, multiple deploys (frontend/backend) etc.

HMTX is also something you should take a look.