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A comment on The serotonin theory of depression: a systematic review of the evidence (2022). Parent comment

Re:The serotonin theory of depression: a systematic review o... by vjk800 on Saturday March 01, 2025 @02:09PM (#43222536)
> There’s also rates of sexual side effects in excess of 70% [1] and they cause weight gain which is separately associated with depression.

I can't find the source now - if someone can, please help me here - but there was a theory that SSRIs work exactly because of the sexual "side effects" (which means that it's not actually a side effect but the main effect). The idea would be that the depression is due to some kind of deeply rooted sexual frustration, which is alleviated when the sex drive vanishes.

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Re:The serotonin theory of depression: a systematic review o... by Johanx64 on Saturday March 01, 2025 @03:38PM (#43223434)
There's also a theory that the reason why SSRIs end up not helping or making things worse in the end is that for males they crush testosterone levels, and if they didn't, they might have been an effective treatment otherwise.
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