> Some antidepressant studies have even been halted because, ironically, the placebo group improved so much that there numerically wasn't much room left for the active group to be statistically better given the sample size.

> but when they finally gave in and did a trial it turned their life around

One might wonder: could this be, in potentially large part, the placebo effect? I suppose that a good answer to that question would be a very big deal.