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Re:The serotonin theory of depression: a systematic review o... by Aurornis on Friday February 28, 2025 @03:29PM (#43210108)
There's actually far more research into what happens after starting an SSRI than you're implying. We know, for example, that certain downstream adaptations takes weeks to fully appear. We also know that the initial increase in serotonin concentrations is limited by 5-HT1A negative feedback, but 5-HT1A downregulates over time and allows the synaptic concentrations to increase again.

> the very fact that scientists can't explain how all this works made me want to stop my treatment and just do more weightlifting and running

Weightlifting and running are complimentary, not substitutive. Most people can't simply replace a powerful medication with more running and weightlifting.

You might also be surprised at how many modern medications operate on partial theories. There's not actually anything wrong with that. There are a lot of medications that hypothetically should work based on scientific understanding of the brain but don't seem to show efficacy in studies.

It's more important that we validate the safety profile and efficacy in real-world testing.

Re:The serotonin theory of depression: a systematic review o... by dondraper36 on Friday February 28, 2025 @03:35PM (#43210231)
I am not saying that quitting SSRIs is the ultimate answer, it just works (sort of) for me mostly because I am not that depressed.

Also, having partial theories is not wrong, but in the case of SSRIs, I deliberately chose to avoid medications that I can do without (again, this is highly subjective).

Another concern of mine is that there are now warnings for some popular SSRIs that ED symptoms in men might be permanent.

Re:The serotonin theory of depression: a systematic review o... by scns on Friday February 28, 2025 @05:07PM (#43212180)
> Another concern of mine is that there are now warnings for some popular SSRIs that ED symptoms in men might be permanent.

They are for some of the unlucky 10%. Buspirone might help.