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Re:The serotonin theory of depression: a systematic review o... by TZubiri on Friday February 28, 2025 @03:21PM (#43209975)
>how little we understand the efficiency of SSRIs

A drug that is taken by millions of people, if your take is that we understand it too little, either you are deep enough in the subject to make some interest questions, or you are missing the forest for the trees.

I'm not sure how useful it is to keep investigating exactly how it works on a chemical level, yeah for sure some people should look into it, but in the same way that some one should do 1600m in the regional competition of Minnesotta, as a niche.

You can observe the effects of the medication on people, done.

I remember seeing a video on a cannabis researcher explaining that they didn't find any difference between the indica and sativa strains for example, and she talked about chemical properties. Just get 10 people to smoke one or the other and you are done.

There is such a thing as overintellectualizing, and FUTON bias isn't a particularly impressive way to do it.

Re:The serotonin theory of depression: a systematic review o... by swores on Friday February 28, 2025 @05:33PM (#43212597)
> "I'm not sure how useful it is to keep investigating exactly how it works on a chemical level"

It has the potential to be incredibly useful.

Not because there's a benefit to being able to tell patients "this is the technical explanation of how the SSRI we're giving you will help", but because we currently don't have a perfect treatment for depression, and understanding how existing imperfect (but useful) treatments actually work might lead to either creating better SSRIs that are more effective, or to creating non-SSRI treatments that we haven't yet thought of.

Re:The serotonin theory of depression: a systematic review o... by TZubiri on Friday February 28, 2025 @06:24PM (#43213175)
>treatment for depression

That reads like a treatment for death, or a solution to poverty.

Will you find the answer by doing 100 metastudies and taking advanced chemistry. Or will you find the wisdom by meditating and talking with your dad and priest.

So I'm either an anti-intellectual, or you are a super-lectual.