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A comment on Decades of Research Misconduct Stalled an Alzheimer's Cure. Parent comment

Re:Decades of Research Misconduct Stalled an Alzheimer's Cure by gregwebs on Sunday February 23, 2025 @06:15PM (#43154170)
It is now well known that serotonin uptake cannot explain the effect of SSRIs and that we don't actually know how they work- but that doesn't mean they don't work. Most drugs have many effects (we call some of them side effects) and this isn't the first drug where we thought we knew how it worked and ended up being wrong.

Some have found flaws with Kirsh's study and there is still an ongoing debate about effectiveness. [1] I am not a fan of prescribing so many people a drug that we don't know how it even works for what is often just a small improvement, but I don't think its accurate to say they are useless.

[1] https://academic.oup.com/ijnp/article/14/3/405/906146#156821...

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Re:Decades of Research Misconduct Stalled an Alzheimer's Cure by ImaCake on Sunday February 23, 2025 @06:19PM (#43154194)
I suspect SSRIs would work a lot better if we could select a better cohort for them. My sister comment notes how depression can be a symptom of a more treatable/precise disorder and so Depression becomes a broad church of several disorders when they present mildly or are not diagnosed for some other reason.
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