> A lot of those are critical prerequisites for humanity's advancement. They also left out some really important stuff like studies on sex in space, exercise in space, effects of radiation in space (as well as hardening electronics), and so on.

Hardening electronics research can be done without pesky humans getting in the way. No need for the ISS.

All the other examples you mentioned are quite circular: humans in space help us research problems we only have because we are putting humans in space.