I prefer it, to the point that I also use the same pattern for my WM with remote and virtual sessions. Keeping the same uniform shortcuts everywhere and just nesting a prefix is a lot easier that having to remember what shortcuts work in what environments. Moving and styling the tmux bar can help (or hurt) keeping muscle-memory mapped to the level you're operating on. At some point, any other approach gets too cognitively complex as you roam and scale[0].

If you only have nested use-cases rarely (or avoid them because you find them cumbersome) I can see how it never sticks but maybe just try leaning into it. YMMV, ofc.

[0]: Please prove me wrong, I'm open to try (: