Re:Dose-dependent effects of LSD in double-blind placebo-con...
by indiantinker on Wednesday February 12, 2025 @12:14PM
(#43027368)
Agreed. I mean n=16 and its on nature.
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Re:Dose-dependent effects of LSD in double-blind placebo-con...
by monkburger on Wednesday February 12, 2025 @02:24PM
(#43028803)
The blinding? Functionally useless UNLESS the researchers genuinely believe subjects couldn't tell whether they were in a psychedelic fugue state or on a placebo. The ketanserin condition? A self-congratulatory exercise in proving that a known 5-HT2A antagonist blocks 5-HT2A-mediated effects. Stunning. rolls eyes
Then there’s the pharmacokinetics section, breathlessly confirming that LSD is absorbed, peaks, and is metabolized..just like every other small-molecule drug with hepatic clearance. The BDNF findings? A biochemical footnote with no functional correlation (tossed in for faux mechanistic depth)