It’s the usual GIGO problem. These arguments almost always start with a bunch of completely made-up numbers. It doesn’t matter how good the math is, the results will be useless.
It can work. When a government regulator decides whether to mandate some new safety equipment and after rigorous technical analysis concludes that it would result in net lives lost and so doesn’t require it, that’s sensible. But thats not what happens here.
I occasionally see this problem acknowledged, but even then, the given error bars are way too small and then it’s just full steam ahead anyway.
It could be dangerous anyway, but this makes it even more so.
I think that a community that engages in brute math with unbounded values for priors to justify action would be worrisome. By choosing the right priors you can conclude almost anything. But I actually think that it is just roughly the same decision making that the rest of the world makes, with an unusual post-facto justification that also feeds one's ego.
I'm not going to walk past a drowning kid in a lake so I can urgently go to a nerd meeting planning to save a quintillion imaginary sci-fi distant future kids - even if some made up math says the expected value of the meeting is a thousand times higher.
Fundamentally, I do have deontological ethics- I think the ancient stoics basically had morality/ethics right, and admire people that take a Socrates like stand on doing what is right on principle even in the face of manipulative people trying to control you by creating bad consequences.