Unless you're like Microsoft (from your link) and accidentally leave the page tables writable from userspace for 2 months. But that's not really a TLB error, that's just L-O-L, wow!
Imagine I'm a user with local shell access trying to read a secret owned by root. Maybe I can't read the secret, but I can do something which makes another program read the secret. If I can make that program swap (perhaps by wasting a bunch of RAM to create memory pressure), and swapping has some probability of triggering a TLB invalidation bug that lets me see the old page, I win, although it might take awhile.
CPython also no longer appears to create RWX mappings even for ctypes, although you can of course still mmap them manually.
I had thought that such V8 optimization were still occuring (as of Chrome Blink81/SparkPlug) during JavaScript execution of untouched bytecode as a form of overhead reduction of its startup.
https://egbert.net/blog/articles/javascript-jit-engines-time...
https://googleprojectzero.blogspot.com/2019/01/taking-page-f...