Sure. I have a 50 year old friend who takes care of her retarded brother. When describing him and what she does, she simply calls him retarded, because he is, and people know what that word means.

One of the kindest women I know, but she doesn't bead around the bush or have time for euphemisms.

Idiot, retard, mentally handicapped, ect. It is all doomed to be a euphemistic treadmill because they can and are used as an insult. The insulting part isn't the word used, but the comparison drawn. Give it 10 years or so and whatever the current word is will also be out of favor as a pejorative.