I run Fedora Kinoite full time on my primary machine, and it's great. Obviously a bit of a learning curve, but if your workflow can be achieved using Flatpaks and Toolbox, it's fine. You can (and I do) layer packages but I have only 3 or so I need to layer (asusctl, supergfxctl and asusctl-rog-gui).

My only real gripe is that Firefox still ships as an rpm in the base image. I understand that they want to include a working web browser at all costs, and I don't think they can distribute the Flatpak version with the base image, but it's annoying that I have to mess with the image (removing Firefox) to then re-install the (more up to date) Flatpak.