Re:Humans are unreliable models of mouse disease
by aphantastic on Saturday December 14, 2024 @04:07PM
(#42419449)
That’s not what I was implying at all I have no clue how you arrived at that. I’m saying an LD1 does exist – it’s the dose that would be fatal to 1% of a population (and further a LD0.1 and 0.0001 exist). These doses are lower than the LD50, fatal to millions, and approach what some would consider normal. For instance: https://www.nbcnews.com/news/amp/ncna759716
Re:Humans are unreliable models of mouse disease
by aphantastic on Saturday December 14, 2024 @05:05PM
(#42419790)
The cooldown period built into HN is there for a reason: taking time to reflect on messages and do any necessary background research makes for better discussions than impulsively saying whatever is top of mind. I suggest you use this time to understand what an LD50 actually is and how the concept generalizes.
(cc @dang, seeing this growing trend of people misunderstanding the missing reply button and evading the timer via edits, perhaps UI affordances could be developed to better introduce folks to the feature?)
The lowest example of a lethal dose I can find in the literature is 57mg/kg. Caffeine overdoses are so rare that we don't know the true distribution, but it's clearly not the case that millions people will die from a few coffees.
Your other comment calculated the lethal dose as *a gallon of espresso*. That's like 125 shots. That is not a remotely normal amount of coffee. It would take multiple people over an hour to make that much espresso for you.