I haven't used this in a few years since switching off of Qubes but something no one mentioned is that output PDFs are *huge*. They're practically PNGs with a .PDF extension in terms of size.

I love the idea of making PDFs dumber and safer but maybe ePub would fit the bill? I'm just thinking out loud, I would like to do this again, but the Qubes way of spinning up a disposable VM to produce a monster PDF file is unsatisfying. More general Qubes being slow was a big reason I switched off of it