If we manage to reproduce the sort of links reddit had in mid 2006, we'll have plenty of startup related stuff mixed in.
I'm sure there will too, but a feature that allows you to only view startup news might be a welcome addition for the portion of news.yc visitors (which I'm guessing is a majority) that come specifically for startup information. At the very least it will differentiate the site from the likes of the MAKE blog, hackszine, etc, which I'm sure will carry a lot of the same content.
While I'm interested in all things hackerly, I first started visiting this site for tips and stories specifically about startups. My point being: while most people here are all for changing the focus to anything hacker-related, I'm sure there are many newcomers who are looking specifically for startup-related info. Perhaps we can retain a sub-site, startup tag or filter that will show only startup news for those people?