Re:RNA-targeting CRISPR reveals that noncoding RNAs are not ...
by robwwilliams on Saturday December 07, 2024 @04:35PM
(#42353027)
Great overview. Worth adding some population genetics: Multicellular organisms typically have small effective population sizes and reproduce slowly in comparison to bacteria. Selection has a hard time “getting a grip” on variants with very weak effects on fitness. Drift becomes much more important.
Bacteria have high population sizes. Selection can be quick and brutal. Low levels of “code of unknown function” in bacteria is perhaps related to replicative efficiency. Fast DNA replication is highly advantageous in nutrient-rich environments. No space (or time) for junk DNA.
To borrow an example: an onion likely doesn’t need 5x more DNA than a human, and a lungfish probably doesn’t need 30 times more than we do (and 350x more than a pufferfish). And yet, these enormous genomes exist. It’s very likely that portions of these sequences are what we’d call “junk,” i.e., DNA that doesn’t confer a meaningful functional advantage and can accumulate due to the relatively low cost of carrying it along.
If we want to avoid the term “junk,” we could say something like “areas of the genome for which we assign a very low prior probability of functional importance.” But “junk” is a concise shorthand to acknowledge that, while some non-coding sequences matter, there are also huge swaths of DNA in many eukaryotes that show no signs of being anything other than evolutionary baggage.