I was at a conference last week, and for the first time heard about a study that suggested that the cycle is that a build up of amyloid, tau, lew bodies, and other metabolic waste in the brain reduces the slow-wave power which is responsible for clearing out this metabolic waste (via the glymphatic system).

This cycle is still not proven, but it was an interesting early hypothosis.

We've been developing slow-wave enhancement technology for the last 4 years which increases slow-wave activity, and the first 3 studies in Alzheimer's and MCI are now published. These are early studies with lots left to go.

Studies https://pmc.ncbi.nlm.nih.gov/articles/PMC10758173/ https://pubmed.ncbi.nlm.nih.gov/37593850/ https://www.proquest.com/intermediateredirectforezproxy

You can find out more about us at https://affectablesleep.com

We're raising an Angel round, and I'll be travelling through the US from Mid-Nov to early Dec. pete[a] domain if you want to learn more.