Do we know? I think that's the question being asked here. Using these drugs seems to improve a bunch of indicators and we're not sure why.

It's really interesting to me that there's some evidence for Metformin -- a diabetes drug that suppresses glucose production and appears to do other things we don't fully understand -- having general health benefits and possible life extending benefits in healthy people. Normally it's just used to treat some forms of diabetes.

Feels like we're on the cusp of figuring something out about inflammation, aging, and metabolism.