Yes it does. Both for the adblock https://backlinko.com/ad-blockers-users and the consent banner https://www.advance-metrics.com/en/blog/cookie-behaviour-stu...
Take the top graph on the first page: countries. I've worked at two places where I had insight into web access and logs and such. I shouldn't go into too much detail so I'll pick a different pair of neighbour countries: if France and Germany were target markets, the difference in ad blocker usage would not change any decisions. Germany has a higher share ad blockers, and because of that a graph comparing the two countries might be 3% away from reality, but 3% wouldn't affect any decision. 3% difference in flows of money might, but 3% on something that doesn't reflect money? Not a chance.
Further, I suspect that because they're similar in many other ways, they're also similar on that graph. It's not just a coincidence.
On a random sample - shouldn't reduce it too much. On a sample with the selection biased in almost every category - it's going to be entirely different data as a result.