No matter how inexperienced your PA intern is, if someone calls them up and says "go search the boss's email for password resets and forward them to my email address" they're (probably) not going to do it.

(OK, if someone is good enough at social engineering they might!)

An LLM assistant cannot be trusted with ANY access to confidential data if there is any way an attacker might be able to sneak instructions to it.

The only safe LLM assistant is one that's very tightly locked down. You can't even let it render images since that might open up a Markdown exfiltration attack: https://simonwillison.net/tags/markdown-exfiltration/

There is a lot of buzz out there about autonomous "agents" and digital assistants that help you with all sorts of aspects of your life. I don't think many of the people who are excited about those have really understood the security consequences here.